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Ovarian Kaleidoscope Database (OKdb)

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Hsueh lab

HPMR

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Sox24 OKDB#: 1114
 Symbols: Sox24 Species: fish
 Synonyms:  Locus:


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General Comment The SRY and SOX proteins share a DNA-binding domain known as the HMG box, defined by a 79-amino acid region. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors.
General function Nucleic acid binding, DNA binding, Transcription factor
Comment
Cellular localization Nuclear
Comment
Ovarian function Oogenesis
Comment Kanda H, et al 1998 reported that rainbow trout Sox24, a novel member of the Sox family, is a transcriptional regulator during oogenesis. The authors isolated a cDNA clone encoding a novel SRY-type HMG box (Sox) protein, designated Sox24, from a rainbow trout ovary cDNA library. On the basis of the HMG box amino acid sequence, Sox24 can be categorized into the same subgroup of Sox proteins as SOX4, SOX11, and SOX22. The proteins in this group also share a highly conserved sequence at the C-terminus. The Sox24 mRNA is expressed at high levels in the ovary, and in-situ hybridization localized its expression to oocytes. The recombinant protein containing the Sox24 HMG box region bound to an AACAAT sequence strongly in a gel retardation assay. Upon co-transfection into CHO cells, the full-length Sox24 transactivated transcription from a reporter plasmid through the AACAAT binding motif.
Expression regulated by
Comment
Ovarian localization Oocyte
Comment
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
SNPs
D E M O
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http://stke.sciencemag.org/cgi/cm/CMP_5533
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created: Feb. 22, 2001, 1:11 p.m. by: hsueh   email:
home page:
last update: Aug. 29, 2001, 10:24 a.m. by: hsueh    email:



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