GPR68 Senses Flow and Is Essential for Vascular Physiology.
A Mechanosensitive GPCR that Detects the Bloody Force. CELL 2018
Xu and Casey (1996) described a gene encoding a member of the G protein-coupled receptors that they termed ovarian
cancer G protein-coupled receptor-1 (OGR1). It was isolated by degenerate PCR from an ovarian cell line cDNA library.
The protein encoded by this gene is a G protein-coupled receptor for sphingosylphosphorylcholine. The encoded protein is a proton-sensing receptor, inactive at pH 7.8 but active at pH 6.8. Mutations in this gene are a cause of amelogenesis imperfecta. [provided by RefSeq, Feb 2017]
Expression regulated by
goes up in a follicle stage-dependent manner in oocytes