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Hsueh lab

HPMR

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NUCLEAR RECEPTOR SUBFAMILY 2, GROUP F, MEMBER 1; NR2F1 OKDB#: 1360
 Symbols: NUCLEAR RECEPTOR SUBFAMILY 2, GROUP F, MEMBER 1; N Species: human
 Synonyms: TRANSCRIPTION FACTOR COUP 1, TFCOUP1| CHICKEN OVALBUMIN UPSTREAM PROMOTER TRANSCRIPTION FACTOR 1, COUPTFI| ERBA-RELATED 3, EAR3| V-ERB-A AVIAN ERYTHROBLASTIC LEUKEMIA VIRAL ONCOGENE HOMOLOG-LIKE 3, ERBAL3|  Locus: 5q14 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment Two 2 ERBA-related genes, named EAR2 and EAR3 , are predicted to encode proteins very similar in primary structure to receptors for steroid hormones and thyroid hormone. In addition, the amino acid sequences of the 2 gene products are very similar to each other, especially in the DNA-binding domain (86% homology) and at the putative ligand-binding domain (76% homology).
General function DNA binding, Transcription factor
Comment
Cellular localization Nuclear
Comment
Ovarian function Ovulation, Luteinization
Comment
Expression regulated by
Comment
Ovarian localization Granulosa
Comment Ying Zhang and Maria L. Dufau 2001 reported that EAR2 and EAR3/COUP-TFI Regulate Transcription of the Rat LH Receptor. hCG treatment significantly reduced the inhibition of LHR gene in granulosa cells and also decreased EAR2 and EAR3/COUP-TFI protein levels. These results indicate that hormonally regulated expression of EAR2 and EAR3/COUP-TFI contributes to gonadotropin-induced derepression of LHR promoter activity in granulosa cells.
Follicle stages Antral
Comment
Phenotypes
Mutations 0 mutations
SNPs
D E M O
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OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: Nov. 2, 2001, 7:34 a.m. by: hsueh   email:
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last update: Nov. 2, 2001, 7:34 a.m. by: system    email:



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