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SECRETED FRIZZLED-RELATED PROTEIN 1; SFRP1 OKDB#: 1686
 Symbols: SECRETED FRIZZLED-RELATED PROTEIN 1; SFRP1 Species: human
 Synonyms: FRIZZLED-RELATED PROTEIN, FRP| SECRETED APOPTOSIS-RELATED PROTEIN 2, SARP2|  Locus: 8p12-p11.1 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment The WNT signaling cascade is involved in regulation of cytoskeletal rearrangements, apoptosis, and proliferation. WNT-mediated simulation of 'frizzled' receptors (e.g., FZD2; OMIM 600667) can activate the beta-catenin (CTNNB1; OMIM 116806) pathway, mitogen-activated protein kinase (MAPK) cascades, and G protein-dependent pathways. The signaling function of the WNT/frizzled pathway is antagonized by secreted frizzled-related proteins , which bind to either WNTs or frizzled receptors. Frizzled-related proteins contain a cysteine-rich domain of approximately 110 residues that is 30 to 40% identical to the putative ligand-binding domain of FZ proteins, but lacks the 7-transmembrane motif that anchors FZ proteins to the plasma membrane.

NCBI Summary: Secreted frizzled-related protein 1 (SFRP1) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP1 and SFRP5 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP1 is expressed in several human tissues, with the highest levels in heart.
General function Extracellular binding protein
Comment
Cellular localization Secreted
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization Theca, Stromal cells
Comment Jabara S, et al 2003 reported stromal cells of the human postmenopausal ovary display a distinctive biochemical and molecular phenotype. The stroma of the human postmenopausal ovary is postulated to produce androgens, but evidence for and against this idea exits in the literature. The purpose of this study was to determine whether key steroidogenic enzymes involved in androgen synthesis are expressed in the postmenopausal ovarian stroma. Stromal cells were isolated from postmenopausal ovaries and expression for genes involved in steroidogenesis [steroidogenic acute regulatory protein (StAR), P450scc, 3beta-hydroxysteroid dehydrogenase (3beta-HSD) P450c17, and P450c27] as well as for several growth factor binding proteins [gremlin, IGF binding protein-4, follistatin, and secreted frizzled-related protein (sFRP)-1 and -4], were compared with cultured human theca cells and dermal fibroblasts. Follistatin, gremlin, IGF binding protein-4, and sFRP-1 and -4 transcripts were detected in the stromal cells in relative amounts significantly higher than theca cells, but not significantly different from fibroblasts, except for sFRP-1, which was significantly higher in stromal cells. The observations demonstrate that stromal cells of the postmenopausal ovary have a signature biochemical and molecular phenotype that can be distinguished from fibroblasts.
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
SNPs
D E M O
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created: Jan. 15, 2003, 2:49 p.m. by: hsueh   email:
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last update: Jan. 15, 2003, 2:49 p.m. by: system    email:



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