Genes of the MAGE family direct the expression of tumor antigens that are recognized on a human melanoma by autologous cytolytic T lymphocytes. The MAGE genes were initially isolated from different kinds of tumors, and based on their virtually exclusive tumor-specific expression in adult tissues, they have been used as targets for cancer immunotherapy. However, although a large number of MAGE genes have now been identified and extensively studied in tumors of various origin, their functions in normal cells remain unknown.
Expression regulated by
Jungbluth AA, et al 2002 reported that CT7 (MAGE-C1) antigen expression in normal and neoplastic tissues, including ovarian carcinomas.