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Hsueh lab

HPMR

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Transporter, Atp-binding Cassette, Major Histocompatibility Complex, 1 OKDB#: 3186
 Symbols: TAP1 Species: human
 Synonyms: APT1, PSF1, ABC17, ABCB2, RING4, TAP1N, D6S114E, FLJ26666, TAP1*0102N,TRANSPORTER, ABC, MHC, 1|ATP-BINDING CASSETTE, SUBFAMILY B, MEMBER 2, ABCB2|ATP-BINDING CASSETTE TRANSPORTER, MAJOR HISTOCOMPATIBILITY COMPLEX, 1|ABC TRANSPORTER, MHC, 1|PEPTIDE TRANSPO  Locus: 6p21.3 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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R-L INTERACTIONS   MGI

DNA Microarrays
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link to BioGPS
General Comment

NCBI Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.
General function Channel/transport protein
Comment
Cellular localization
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization
Comment
Follicle stages Primordial
Comment Arraztoa JA, et al 2005 reported the identification of genes expressed in primate primordial oocytes.
Phenotypes
Mutations 0 mutations
SNPs
D E M O
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
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created: June 21, 2006, 12:44 p.m. by: alex   email:
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last update: June 21, 2006, 1:29 p.m. by: alex    email:



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