|Interleukin Enhancer-binding Factor 3||OKDB#: 3334|
|Synonyms:||DRBF, MMP4, MPP4, NF90, NFAR, TCP80, DRBP76, NFAR-1, MPHOSPH4, NF-AT-90,NUCLEAR FACTOR OF ACTIVATED T CELLS, 90-KD, NF90|DOUBLE-STRANDED RNA-BINDING PROTEIN, 76-KD, DRBP76|M-PHASE PHOSPHOPROTEIN 4, MPP4, MPHOSPH4|NUCLEAR FACTOR ASSOCIATED WITH DOUBLE-STRA||Locus:||19p13.2 in Homo sapiens|
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R-L INTERACTIONS MGI
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NCBI Summary: Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of interleukin 2. NFAT binds to a sequence in the IL2 enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene. The encoded protein, which is primarily localized to ribosomes, probably regulates transcription at the level of mRNA elongation. At least three transcript variants encoding three different isoforms have been found for this gene.
|General function||Nucleic acid binding, DNA binding, Transcription factor|
|Ovarian function||Oogenesis, Oocyte maturation|
|Comment||Gene whose expression is detected by cDNA array hybridization: cell surface antigens, cell adhesion, receptors Rozenn Dalbis-Tran and Pascal Mermilloda|
|Expression regulated by|
|Genomic Region||show genomic region|
|Phenotypes and GWAS||show phenotypes and GWAS|
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|created:||July 18, 2006, 10:26 a.m.||by:||
|last update:||July 26, 2006, 2:20 p.m.||by:||Alex email:|
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