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Hsueh lab

HPMR

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Neuromedin U Receptor 1 OKDB#: 3710
 Symbols: NMUR1 Species: human
 Synonyms: FM3, FM-3, GPC-R, GPR66, NMU1R, (FM-3),NMU1R|G PROTEIN-COUPLED RECEPTOR 66, GPR66|GROWTH HORMONE SECRETAGOGUE RECEPTOR FAMILY, MEMBER 3, FM3  Locus: 2q37.1 in Homo sapiens
HPMR


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment
General function Receptor
Comment
Cellular localization Plasma membrane
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization
Comment Expression of neuromedins S and U and their receptors in the hypothalamus and endocrine glands of the rat. Rucinski M et al. Neuromedin S (NMS) and neuromedin U (NMU) are regulatory peptides that share the C-terminal amino-acid sequence and act via common G protein-coupled receptors called NMUR1 and NMUR2. Semiquantitative real time-PCR showed that in the rat hypothalamus and testis NMS gene expression was markedly higher than that of the NMU gene, while the reverse occurred in the anterior pituitary and thyroid gland. Low expression of both genes was detected in the thymus, adrenal gland and ovary, whereas in the pancreatic islets only the expression of NMU mRNA was detected. In the rat hypothalamus the expression of the NMUR2 gene was strikingly higher than that of the NMUR1 gene; in contrast, in the testis and ovary the very low expression of NMUR2 contrasted with the relatively high expression of the NMUR1 gene. In the other glands examined only expression of the NMUR1 gene was found. The marked differences in the level of expression of NMU, NMS and their receptors in the hypothalamus and endocrine glands of the rat suggest that in this species such neuromedins may play different roles in the functional regulation of neuroendocrine axes.
Follicle stages
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Phenotypes
Mutations 0 mutations
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D E M O
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created: July 11, 2007, 2:23 p.m. by: hsueh   email:
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last update: July 11, 2007, 2:23 p.m. by: hsueh    email:



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