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Hsueh lab

HPMR

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176557

Ets Variant Gene 5 OKDB#: 3788
 Symbols: ETV5 Species: human
 Synonyms: ERM,ETS-RELATED MOLECULE, ERM  Locus: 3q28 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment
General function Nucleic acid binding, DNA binding, Transcription factor
Comment
Cellular localization Nuclear
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization Cumulus, Granulosa
Comment ERM, an ETS transcription factor, is expressed in granulosa and cumulus cells and serves as a transcriptional regulator of the cyclooxygenase-2. Eo J et al. PEA3, ER81, and ERM are members of PEA3 subfamily of E26 transformation-specific (ETS) transcription factors which are known to influence a host of biological processes. We previously showed that ERM, expressed in Sertoli cells, plays a crucial role in maintaining spermatogonial stem cell niche in the mouse testis. However, it is not yet known whether PEA3 family members are expressed in the ovary or play any role in ovarian functions. Here we show that ERM and PEA3 are expressed in mouse ovaries in granulosa and cumulus cells during folliculogenesis. Both ERM and PEA3 mRNAs are also detected in cumulus-oocyte-complexes (COCs) and in denuded oocytes. Notably, PEA3 is highly expressed in the cumulus cells of ovulated COCs at 16 hr post-hCG. Cyclooxygenase-2 (COX-2), a rate-limiting enzyme for prostaglandin synthesis, is critical for oocyte maturation and ovulation. Since several putative ETS-binding sites (EBS) are present in the COX-2 promoter, we examined whether ERM influences COX-2 transcriptional activity. Indeed, we found that addition of ERM increases the transcriptional activity of the 3.2-kb mCOX-2 promoter by 2.5 fold in luciferase reporter assays. Collectively, the results show that PEA3 and ERM are expressed in granulosa and cumulus cells during folliculogenesis and ovulation, suggesting they influence cellular events in the ovary by regulating downstream genes such as COX-2.
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
SNPs
D E M O
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: June 4, 2008, 2:14 p.m. by: hsueh   email:
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last update: June 4, 2008, 2:15 p.m. by: hsueh    email:



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