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Hsueh lab

HPMR

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Alpha-2a-adrenergic Receptor OKDB#: 4108
 Symbols: ADRA2A Species: human
 Synonyms: ADRA2, ADRAR, ZNF32, ADRA2R, ALPHA2AAR,ADRAR|ALPHA-2-ADRENERGIC RECEPTOR, PLATELET TYPE|ADRENOCEPTOR, ALPHA-2A, ADRA2  Locus: 10q24-q26 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment

NCBI Summary: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq]
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Expression regulated by
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created: July 18, 2009, 8:12 a.m. by: hsuehlab   email:
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