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Ovarian Kaleidoscope Database (OKdb)

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Hsueh lab

HPMR

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Receptor Neuropilin 2 OKDB#: 1583
Symbols: NRP2 Species: human
Synonyms: NPN2|VASCULAR ENDOTHELIAL GROWTH FACTOR-165 RECEPTOR 2, VEGF165R2| Ovarian localization: Theca, Luteal cells
Is involved in interactions with:

1)
SEMA3C, Semaphorin 3C OKdb  (Ovarian localization: )
Comments: Takahashi T, et al.(Nat Neurosci. 1998) demostrated that semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors.

2)
KDR, Vascular endothelial growth factor receptor 2 precursor OKdb  (Ovarian localization: Oocyte Granulosa Theca Luteal Lutealsmall Luteallarge)
  and
VEGFC, vascular endothelial growth factor C OKdb  (Ovarian localization: Granulosa Luteal)
Comments: Joukov V., et al.(Embo J, 1996) found that VEGFC is a novel ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.

3)
SEMA3F, Semaphorin 3F HPMR (NOT-IN-OKDB)
  and
PLXNA3, Plexin A3 [Precursor] HPMR (NOT-IN-OKDB)
Comments: Plexin-A3 and -A4 together mediate the responses to class 3 Semaphorins in sensory and sympathetic neurons, with Plexin-A4 being principally responsible for mediating responses to Sema3A via Neuropilin-1 and Plexin-A3 being principally responsible for responses to Sema3F via Neuropilin-2 (Yaron et al. 2005).

4)
KDR, Vascular endothelial growth factor receptor 2 precursor OKdb  (Ovarian localization: Oocyte Granulosa Theca Luteal Lutealsmall Luteallarge)
  and
FIGF, c-fos induced growth factor (vascular endothelial growth factor D) OKdb  (Ovarian localization: Granulosa Luteal)
  and
FLT4, Vascular endothelial growth factor receptor 3 precursor OKdb  (Ovarian localization: Oocyte)
Comments: Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). Proc Natl Acad Sci U S A. 1998

5)
FIGF, c-fos induced growth factor (vascular endothelial growth factor D) OKdb  (Ovarian localization: Granulosa Luteal)
Comments: Functional interaction of VEGF-C and VEGF-D with neuropilin receptors. FASEB J. 2006

Data Supplied By HPMR